Discovery of New Biomotors Similar to the Earth Revolving around the Sun without Rotation and Related W



报告题目:Discovery of New Biomotors Similar to the Earth Revolving around the Sun without Rotation and Related Work in RNA Nanotechnology and Single Molecular Sensing

报告人:郭培宣 教授(肯塔基大学)





Peixuan Guo received his Ph.D. from the University of Minnesota in 1987; was a post-doc at NIH before joining Purdue University as an assistant professor in 1990, was tenured in 1993, became a full Professor in 1997, and was honored as a Purdue Faculty Scholar in 1998, and served as the Director of the NIH Nanomedicine Development Center from 2006-2011. He was recruited to the University of Cincinnati as Endowed Chair of Biomedical Engineering in 2007; recruited to University of Kentucky as William Farish Endowed chair in nanobiotechnology in 2012. Currently, he is the Director of NCI Cancer Nanotech Platform Partnership Program: "RNA Nanotech for Cancer Therapy"

He constructed phi29 DNA packaging motor (PNAS, 1986), discovered phi29 motor pRNA (Science, 1987), discovered the pRNA hexamer (Mol Cell, 1998; featured in Cell), and pioneered RNA nanotechnology (Mol Cell, 1998, Nature Nanotech 2009, 2010, 2011). His lab built a sensitive dual single fluorophores detection system (EMBO J, 2007), and incorporated phi29 motor channel into a lipid membrane (Nature Nanotech, 2009) for single molecule sensing with potentials for single pore dsDNA sequencing. Recently, his team discovered a new mechanism of hexameric viral DNA packaging motor that utilizes a revolution mechanism without rotation. This finding has corrected the misperception of pentameric rotation motor, a theory that was popular for several decades.

He received the Pfizer Distinguished Faculty Award in 1995; Purdue Faculty Scholar award in 1998; Lions Club Cancer Research Award in 2006; and Distinguished Alumni of the University of Minnesota in 2009, Distinguished Research Faculty Award in 2010 and 2011. He is an editor/board member of five nanotech journals. His work has been aired hundreds of times over the radio and TV stations such as ABC and NBC, and featured in newsletters of NIH, NSF, MSNBC, NCI, and ScienceNow, to name a few. He was a member of two prominent national nanotech initiatives sponsored by NIST, NIH, NSF and the National Council of Nanotechnology; and a member of the NIH NDC Steering Committee from 2006-2010.